Natural History of Saccular Aortic Aneurysms

نویسندگان
چکیده

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Congenital Saccular Aneurysms of the Aortic Ring

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Autosomal dominant inheritance of a predisposition to thoracic aortic aneurysms and dissections and intracranial saccular aneurysms.

A genetic predisposition for thoracic aortic aneurysms and dissections (TAAD) can be inherited in an autosomal dominant manner with decreased penetrance and variable expression. Four genes identified to date for familial TAAD account for approximately 20% of the heritable predisposition. In a cohort of 514 families with two or more members with presumed autosomal dominant TAAD, 48 (9.3%) famili...

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ژورنال

عنوان ژورنال: Journal of Vascular Surgery

سال: 2012

ISSN: 0741-5214

DOI: 10.1016/j.jvs.2011.11.084